Nature

A prospective phase 2 clinical trial of a C5a complement inhibitor for acute GVHD with lower GI tract involvement

Involvement of lower gastrointestinal tract (LGI) occurs in 60% of patients with graft-versus-host-disease (GVHD). Complement components C3 and C5 are involved in GVHD pathogenesis. In this phase 2a ...
MedPage Today

In NMOSD, Could Inhibiting Complement C5a Help Reduce Pain?

Complement C5a is a known mediator of inflammatory and neuropathic pain. In a new study, patients with NMOSD who were in remission and healthy controls were asked to rate their pain on a visual analog ...
Business Insider

NovelMed's Complement Alternative Pathway Specific Anti-Bb Antibody (NM8074) for Rare Diseases Achieves a Major Milestone

CLEVELAND, Jan. 31, 2022 /PRNewswire/ -- NovelMed Therapeutics announced today that its Investigational New Drug Application (IND) to initiate clinical trials of its NM8074 biologic has been cleared ...
Nature

The temporal gene expression landscape of rhabdomyolysis-induced acute kidney injury reveals the timing of complement activation

Acute kidney injury (AKI) is a common complication of numerous acute illnesses and is associated with increased mortality regardless of its etiology 1. AKI may occur because of medication ...